Police have launched a major investigation to find a boy with a brain tumour, taken without consent from hospital by his parents.
Hampshire Constabulary said "there are serious concerns" for the life of Ashya King as he needs constant medical care.
Officers said his parents - Brett King, 51, and Naghemeh King, 45, - boarded a cross-Channel ferry from Portsmouth to Cherbourg at 4pm yesterday.
The parents went with Ashya's six siblings, officers said.
Police said Ashya was taken from Southampton General Hospital at around 2pm yesterday by his family, who live in St David's Road, Southsea, Portsmouth.
CCTV images captured the moment the boy was wheeled out of the hospital, apparently by his father.
Ashya is still likely to be in a wheelchair or buggy, he cannot communicate verbally and is immobile, a police spokesman said.
The family are travelling in a grey-coloured Hyundai I800 Style CRDI, registration KP60 HWK, and they are still believed to be in France.
Police said they arrived in France at 8pm local time last night.
Hampshire Constabulary said: "We are working with our counterparts in France to activate their emergency child rescue alert procedures to locate the family as soon as possible.
"If we do not locate Ashya today there are serious concerns for his life.
"He is receiving constant medical care within the UK due to recent surgery and ongoing medical issues.
"Without this specialist 24-hour care Ashya is at risk of additional health complications which place him at substantial risk."
In a video posted on YouTube last month, Naveed King said his little brother Ashya had been diagnosed with a brain tumour and was undergoing emergency surgery.
Speaking into the camera in a message directly to Ashya, he said: "I haven't slept. I've been awake all night worrying.
"We love you so much. We're all here for you. "Everyone is praying for you. We just want to see your smile again.
"No kid at the age of five deserves to have a brain tumour.
"Let's just hope the doctors know what they're doing and they know exactly where to operate and what to take out, and they take everything out and you can be better.
"And when we look back in 10 years' time when you're 15, we can actually see that things have changed for the better.
"Just because they're bad at one point doesn't mean they'll always be bad.
"I love you so much. I can't wait to see you."
Detective Superintendent Dick Pearson, of the Hampshire Major Investigation Team, said: "He needs to be taken to a medical facility for his urgent health requirements as soon as he is located.
"We have also launched a social media appeal and would urge everyone to share this appeal, particularly if you have friends and relatives in France and bordering countries."
Anyone with information about Ashya's whereabouts should contact Hampshire Constabulary on 101, quoting Operation Aquilion.
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https://uk.news.yahoo.com/major-investigation-boy-taken-hospital-063909929.html
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